Research

Since 2015, the International Institute of DAO Deficiency has been involved
in several published scientific studies and posters at congresses.

Tormo, R.; Duelo, A.; Segurola, H.; Cárdenas, G. Longitudinal exploratory study on dietary treatment in patients with migraine and other functional symptoms associated with DAO deficiency. Oral presentation INFARMA Congress, 2015.

Izquierdo-Casas, J., Comas-Basté, O., Latorre-Moratalla, M. L., Lorente-Gascón, M., Duelo, A., Vidal-Carou, M. C., & Soler-Singla, L. (2017). Low serum diamine oxidase (DAO) activity levels in patients with migraine. Journal of physiology and biochemistry, 74(1), 93–99. https://doi.org/10.1007/s13105-017-0571-3

Duelo, A., Berbel, M., Mantecon-Laviguerie, H., Comas-Basté, O., Latorre-Moratalla, M.L., Veciana- Nogués, M.T., Vidal-Carou, M.C. Low-histamine diet supplemented with exogenous diamine oxidase enzyme is useful for treating migraine in patients with DAO deficiency. Ann Nutr Metab. 2018

Izquierdo-Casas, J., Comas-Basté, O., Latorre-Moratalla, M. L., Lorente-Gascón, M., Duelo, A., Soler-Singla, L., & Vidal-Carou, M. C. (2019). Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial. Clinical nutrition (Edinburgh, Scotland), 38(1), 152–158. https://doi.org/10.1016/j.clnu.2018.01.013

Duelo, A. Low-histamine diet treatment to two patients with migraine and diamine oxidase deficiency. Journal or negative & no positive results. 2019.
https://doi.org/10.19230/jonnpr.3036

Sánchez-Pérez, S., Comas-Basté, O., Duelo, A., Veciana-Nogués, M. T., Berlanga, M., Vidal-Carou, M. C., & Latorre-Moratalla, M. L. (2022). The dietary treatment of histamine intolerance reduces the abundance of some histamine-secreting bacteria of the gut microbiota in histamine intolerant women. A pilot study. Frontiers in nutrition, 9, 1018463. https://doi.org/10.3389/fnut.2022.1018463

Sánchez-Pérez, S., Comas-Basté, O., Duelo, A., Veciana-Nogués, M. T., Berlanga, M., Latorre-Moratalla, M. L., & Vidal-Carou, M. C. (2022). Intestinal Dysbiosis in Patients with Histamine Intolerance. Nutrients, 14(9), 1774. https://doi.org/10.3390/nu14091774

Blasco-Fontecilla, H., Wang, P., Li, C., Duelo, A., Ruiz-Casares, E., Perucho, T. (2022). Prevalencia y perfil clínico de la deficiencia de diamino oxidasa (DAO) en pacientes con trastorno por déficit de atención e hiperactividad (TDAH). Revista de Psiquiatría infanto-Juvenil, 39 (1).

Okutan, G., Perucho-Alcalde, T., Ruiz-Casares, E., Penadés, B., Sánchez-Niño, M., Terrén-Lora,  A., López-Oliva, S., Torrente- Estríngana, L., Duelo, A., San Mauro-Martín, I. (2023). Cumulative effect of AOC1 gene variants on symptoms and pathological conditions in adult women with fibromyalgia: a pilot study. Frontiers, 14. https://doi.org/10.3389/fgene.2023.1180777

Duelo, A., Comas-Basté, O., Sánchez-Pérez, S., Veciana-Nogués, M. T., Ruiz-Casares, E., Vidal-Carou, M. C., & Latorre-Moratalla, M. L. (2024). Pilot Study on the Prevalence of Diamine Oxidase Gene Variants in Patients with Symptoms of Histamine Intolerance. Nutrients, 16(8), 1142. https://doi.org/10.3390/nu16081142