What is DAO Institute
Advancing knowledge in histamine metabolism and DAO Deficiency.
The International Institute of DAO Deficiency (DAO Institute) is a research, education, and knowledge-transfer organization dedicated to the scientific study and clinical understanding of Diamine Oxidase (DAO) Deficiency and its central role in the regulation of histamine metabolism. The Institute focuses on looking into the physiological function of DAO, the mechanisms leading to reduced enzymatic activity, and the systemic clinical implications associated with impaired histamine degradation and evidence-based treatment protocols grounded in the most recent scientific and clinical findings.
We collaborate with universities, hospitals, analytical laboratories, clinical research units, and biomedical institutions to support observational studies, clinical trials, translational research, and the development of diagnostic and therapeutic tools for DAO Deficiency. A core aim of the Institute is to contribute to the standardization of diagnostic criteria and laboratory methodologies, as well as to develop structured approaches for patient stratification and clinical management.
Key Areas of Work
• Translational and clinical research on histamine metabolism and its relationship with gastrointestinal, neurological, dermatological, respiratory and musculoskeletal manifestations
• Development of clinical practice protocols for the assessment, diagnosis, and comprehensive management of DAO Deficiency.
• Professional education and certification programs for medical doctors, registered dietitians, psychologists, and allied healthcare professionals.
• Scientific communication and patient-oriented education, providing reliable resources for individuals seeking to understand and manage their condition.
• Promotion of cross-disciplinary collaboration, facilitating the integration of new findings into medical practice and healthcare systems.
Global Technological Platform
The DAO Institute promotes and coordinates a global technological platform designed to connect specialized healthcare professionals with the patient population, estimated at approximately 10% of the general population. This platform supports:
- Access to specialists trained and licensed in DAO Deficiency management.
- Standardized clinical pathways and referral networks.
- Shared knowledge, case discussion, and ongoing professional development.
- Secure patient navigation toward evidence-based care.
Objectives
Improving patient outcomes and quality of life through early detection and personalized management strategies.
Developing an international community of DAO Deficiency specialists connected through a structured licensing framework and the Institute’s digital platform.
Facilitating direct specialist–patient connectivity through guided clinical pathways.
Promoting awareness and scientific understanding of DAO Deficiency across biological, physiological, clinical, diagnostic, therapeutic, and preventive dimensions.
Ensuring the translation of research outcomes into healthcare systems, benefiting patients through improved diagnosis and treatment.
Supporting the development and optimization of healthcare and nutritional products that enhance daily living for patients.
Carrying out related lawful activities consistent with advancing the Institute’s mission.
To award KOL (Key Opinion Leader) status at the highest level of training to the most advanced members of DAO Institute, recognising their expertise, leadership, and contribution to the field
To provide an enzymatic quality certification for products that meet defined minimum standards, ensuring validated efficacy, reliability, and scientific rigour.
Activities
• Conducting scientific and clinical research on DAO Deficiency.
• Promoting and organizing conferences, professional training programs, collaborative studies, and research initiatives.
• Coordinating public education, scientific dissemination, and preventive health campaigns.
• Establishing relationships with regulatory authorities, scientific societies, medical institutions, and patient associations.
• Forming partnerships with biotechnology, healthcare, and nutritional innovation companies to foster translational application and technology development.
Mission
Our mission is to support precise, evidence-based clinical practice that enables earlier diagnosis, more effective clinical interventions, and improved quality of life for individuals with DAO Deficiency. The DAO Institute operates under principles of scientific rigor, continuous advancement, and multidisciplinary collaboration, contributing to a clearer understanding and better clinical management of this metabolic condition.