{"id":6661,"date":"2025-12-11T12:13:18","date_gmt":"2025-12-11T11:13:18","guid":{"rendered":"https:\/\/www.daodeficiencyinstitute.com\/investigacion\/"},"modified":"2026-04-08T13:13:18","modified_gmt":"2026-04-08T11:13:18","slug":"investigacion","status":"publish","type":"page","link":"https:\/\/www.daodeficiencyinstitute.com\/es\/investigacion\/","title":{"rendered":"Investigaci\u00f3n"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"6661\" class=\"elementor elementor-6661 elementor-6022\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63e006b e-flex e-con-boxed e-con e-parent\" data-id=\"63e006b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2cdfc6d elementor-widget elementor-widget-image\" data-id=\"2cdfc6d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1548\" height=\"675\" src=\"https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/research-dao-institute.jpg\" class=\"attachment-full size-full wp-image-5914\" alt=\"\" srcset=\"https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/research-dao-institute.jpg 1548w, https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/research-dao-institute-300x131.jpg 300w, https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/research-dao-institute-1024x447.jpg 1024w, https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/research-dao-institute-768x335.jpg 768w, https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/research-dao-institute-1536x670.jpg 1536w, https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/research-dao-institute-600x262.jpg 600w\" sizes=\"(max-width: 1548px) 100vw, 1548px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8b23e38 elementor-widget elementor-widget-heading\" data-id=\"8b23e38\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Investigaci\u00f3n<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1219429 elementor-widget elementor-widget-heading\" data-id=\"1219429\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Nuestro trabajo<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-975a091 elementor-widget elementor-widget-text-editor\" data-id=\"975a091\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Nuestra investigaci\u00f3n se centra en los fundamentos biol\u00f3gicos, las manifestaciones cl\u00ednicas y las implicaciones terap\u00e9uticas del D\u00e9ficit de DAO.<br><br>Analizamos los factores enzim\u00e1ticos, gen\u00e9ticos, metab\u00f3licos y nutricionales que contribuyen a una degradaci\u00f3n deficiente de la histamina y evaluamos su impacto en patolog\u00edas como los trastornos gastrointestinales funcionales, la cefalea y la migra\u00f1a, la urticaria y otros s\u00edntomas sist\u00e9micos asociados al exceso de histamina. <\/p><p>Este enfoque multidisciplinar integra investigaci\u00f3n de laboratorio, estudios cl\u00ednicos observacionales, ensayos de intervenci\u00f3n y el desarrollo de herramientas diagn\u00f3sticas<br>y terap\u00e9uticas, con el objetivo de garantizar que los avances cient\u00edficos se traduzcan en beneficios reales y tangibles para los pacientes a nivel global.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1d11010 e-flex e-con-boxed e-con e-parent\" data-id=\"1d11010\" data-element_type=\"container\" data-e-type=\"container\" id=\"publications\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0ef892d elementor-widget elementor-widget-heading\" data-id=\"0ef892d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Publicaciones cient\u00edficas <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-993da51 elementor-widget elementor-widget-text-editor\" data-id=\"993da51\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Esta secci\u00f3n recopila publicaciones cient\u00edficas coautoradas por Adriana Duelo y otros miembros del Instituto, que abordan temas clave como la bioqu\u00edmica de la DAO, el metabolismo de la histamina, los fenotipos cl\u00ednicos del d\u00e9ficit de DAO, su etiolog\u00eda subyacente, la terapia nutricional, las metodolog\u00edas diagn\u00f3sticas y los resultados de la suplementaci\u00f3n enzim\u00e1tica.<br>Estas publicaciones contribuyen al cuerpo global de evidencia cient\u00edfica y respaldan la misi\u00f3n del Instituto de impulsar una investigaci\u00f3n rigurosa y de alta calidad en este \u00e1mbito:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1943052 e-con-full e-flex e-con e-child\" data-id=\"1943052\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d756399 elementor-widget elementor-widget-text-editor\" data-id=\"d756399\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><small><strong>2025 | Duelo, A<\/strong>; S\u00e1nchez-P\u00e9rez, S.; Pellicer-Roca, S.; S\u00e1nchez-Buxens, S.; Comas-Bast\u00e9, O.; Latorre-Moratalla, M.L.; Vidal-Carou, M.C.<\/small><br><strong>Improvement of Histamine Intolerance Symptoms in Pregnant Women with Diamine Oxidase Deficiency: An Exploratory Study.<\/strong><br><small>J. Clin. Med. 2025, 14, 4573. <\/small><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1195272 e-con-full e-flex e-con e-child\" data-id=\"1195272\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-40fb44d elementor-widget elementor-widget-text-editor\" data-id=\"40fb44d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><small><strong>2024 | Duelo, A<\/strong>; S\u00e1nchez-P\u00e9rez, S.; Ruiz-Leon, A.M.; Casanovas-Garriga, F.; Pellicer-Roca, S.; Iduriaga-Platero, I.; Costa-Catala, J.; Veciana-Nogu\u00e9s, M.T.; Fern\u00e1ndez-Sol\u00e0, J.; Mu\u00f1oz-Cano, R.M.; et al.<\/small><br><strong>Study Protocol for a Prospective, Unicentric, Double-Blind, Randomized, and Placebo-Controlled Trial on the Efficacy of a Low-Histamine Diet and DAO Enzyme Supplementation in Patients with Histamine Intolerance.<\/strong><br><small>Nutrients 2025, 17, 29.<\/small><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-08695ca e-con-full e-flex e-con e-child\" data-id=\"08695ca\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-46ce1e9 elementor-widget elementor-widget-text-editor\" data-id=\"46ce1e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><small><strong>2024 | Duelo, A<\/strong>; Comas-Bast\u00e9, O.; S\u00e1nchez-P\u00e9rez, S.; Veciana-Nogu\u00e9s, M.T.; Ruiz-Casares, E.; Vidal-Carou, M.C.; Latorre-Moratalla, M.L.<\/small><br><strong>Pilot Study on the Prevalence of Diamine Oxidase Gene Variants in Patients with Symptoms of Histamine Intolerance.<\/strong><br><small>Nutrients 2024, 16, 1142.<\/small><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e089855 elementor-align-justify elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"e089855\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.3390\/nu16081142\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Art\u00edculo completo<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d9545d4 e-con-full e-flex e-con e-child\" data-id=\"d9545d4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-53559bc elementor-widget elementor-widget-text-editor\" data-id=\"53559bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><small><strong>2023<\/strong> | Okutan, G.; Perucho Alcalde, T.; Ruiz Casares, E.; Penad\u00e9s, B. F.; S\u00e1nchez Ni\u00f1o, G. M.; Terr\u00e9n Lora, A.; L\u00f3pez Oliva, S.; Torrente Estr\u00edngana, L.; <strong>Duelo, A.<\/strong>; San Mauro Mart\u00edn, I.<\/small><br><strong>Cumulative effect of AOC1 gene variants on symptoms and pathological conditions in adult women with fibromyalgia: a pilot study.<\/strong><br><small>Frontiers in genetics 2023, 14, 1180777. <\/small> <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f5c120f elementor-align-justify elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"f5c120f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.3389\/fgene.2023.1180777\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Art\u00edculo completo<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aab3a3f e-con-full e-flex e-con e-child\" data-id=\"aab3a3f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ccc32dd elementor-widget elementor-widget-text-editor\" data-id=\"ccc32dd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><small><strong>2022<\/strong> | S\u00e1nchez-P\u00e9rez, S.; Comas-Bast\u00e9, O.; <strong>Duelo, A.<\/strong>; Veciana-Nogu\u00e9s, M. T.; Berlanga, M.; Vidal-Carou, M. C.; Latorre-Moratalla, M. L.<\/small><br><strong>The dietary treatment of histamine intolerance reduces the abundance of some histamine-secreting bacteria of the gut microbiota in histamine intolerant women.<\/strong><br><small>Frontiers in genetics 2023, 14, 1180777. <\/small> <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8b0b75d elementor-align-justify elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"8b0b75d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.3389\/fnut.2022.1018463\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Art\u00edculo completo<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6ccf575 e-con-full e-flex e-con e-child\" data-id=\"6ccf575\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-af15eb8 elementor-widget elementor-widget-text-editor\" data-id=\"af15eb8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><small><strong>2022 |<\/strong> S\u00e1nchez-P\u00e9rez, S., Comas-Bast\u00e9, O., <strong>Duelo, A.<\/strong>, Veciana-Nogu\u00e9s, M. T., Berlanga, M., Latorre-Moratalla, M. L., &amp; Vidal-Carou, M. C.<\/small><br><strong>Intestinal Dysbiosis in Patients with Histamine Intolerance.<\/strong><br><small>Nutrients, 14(9), 1774.<\/small><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-943052a elementor-align-justify elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"943052a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.3390\/nu14091774\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Art\u00edculo completo<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1d3a52a e-con-full e-flex e-con e-child\" data-id=\"1d3a52a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-95c19d1 elementor-widget elementor-widget-text-editor\" data-id=\"95c19d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><small><strong>2022<\/strong> | Blasco, H.; Wang, P.; Li, C.; <strong>Duelo, A.<\/strong>; Ruiz, E.; Perucho, T.  <\/small><br><strong>Prevalencia y perfil cl\u00ednico de la deficiencia de diamino oxidasa (DAO) en pacientes con trastorno por d\u00e9ficit de atenci\u00f3n e hiperactividad (TDAH).<\/strong><br><small>Revista de Psiquiatr\u00eda Infanto-Juvenil. Vol. 39, Supl.   1.  <\/small><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-326301e e-con-full e-flex e-con e-child\" data-id=\"326301e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cec82fb elementor-widget elementor-widget-text-editor\" data-id=\"cec82fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><small><strong>2019 | Duelo, A.<\/strong> <\/small><br><strong>Low-histamine diet treatment to two patients with migraine and diamine oxidase deficiency.<\/strong><br><small>Journal or negative &amp; no positive results. 2019.<\/small><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-84d59af elementor-align-justify elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"84d59af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.19230\/jonnpr.3036\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Art\u00edculo completo<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4d6f50e e-con-full e-flex e-con e-child\" data-id=\"4d6f50e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ce7898a elementor-widget elementor-widget-text-editor\" data-id=\"ce7898a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><small><strong>2018<\/strong> | Izquierdo-Casas, J.; Comas-Bast\u00e9, O.; Latorre-Moratalla, M.L.; Lorente-Gasc\u00f3n, M.; <strong>Duelo, A.<\/strong>; Soler-Singla, L.; Vidal-Carou, M.C.  <\/small><br><strong>Diamine Oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: a randomized double-blind trial.<\/strong><br><small>Clinical Nutrition. 2018.<\/small><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2d76ab0 elementor-align-justify elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"2d76ab0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.1016\/j.clnu.2018.01.013\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Art\u00edculo completo<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7a53b39 e-con-full e-flex e-con e-child\" data-id=\"7a53b39\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4040bfc elementor-widget elementor-widget-text-editor\" data-id=\"4040bfc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><small><strong>2018 | Duelo, A.<\/strong>, Berbel, M., Mantecon-Laviguerie, H., Comas-Bast\u00e9, O., Latorre-Moratalla, M.L., Veciana-Nogu\u00e9s, M.T., Vidal-Carou, M.C. <\/small><br><strong>Low-histamine diet supplemented with exogenous diamine oxidase enzyme is useful for treating migraine in patients with DAO deficiency .<\/strong><br><small>Ann Nutr Metab.<\/small><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9e0a254 e-con-full e-flex e-con e-child\" data-id=\"9e0a254\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4d24b91 elementor-widget elementor-widget-text-editor\" data-id=\"4d24b91\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><small><strong>2018-2017 |<\/strong> Izquierdo-Casas, J., Comas-Bast\u00e9, O., Latorre-Moratalla, M.L., Lorente-Gasc\u00f3n, M., <strong>Duelo, A.<\/strong>, Vidal-Carou, M.C. Soler-Singla, L.,<\/small><br><strong>Low serum diamine oxidase (DAO) activity levels in patients with migraine.<\/strong><br><small>Journal of Physiology and Biochemistry. 2017.<\/small><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7196a94 elementor-align-justify elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"7196a94\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/doi.org\/10.1007\/s13105-017-0571-3\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Art\u00edculo completo<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1df3c8f e-flex e-con-boxed e-con e-parent\" data-id=\"1df3c8f\" data-element_type=\"container\" data-e-type=\"container\" id=\"innovation\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-23a0d8c elementor-widget elementor-widget-heading\" data-id=\"23a0d8c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Innovaci\u00f3n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-963350d elementor-widget elementor-widget-heading\" data-id=\"963350d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">M\u00e1s de 15 a\u00f1os impulsando la innovaci\u00f3n en DAO<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1bab864 elementor-widget elementor-widget-text-editor\" data-id=\"1bab864\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Juanjo Duelo<\/strong>, presidente del Consejo del DAO Institute, es ampliamente reconocido como uno de los pioneros en el avance de la investigaci\u00f3n cient\u00edfica sobre la enzima diamino oxidasa (DAO) y sus implicaciones cl\u00ednicas.<\/p><p>En 2007, fund\u00f3 <strong>DR Healthcare<\/strong>, una compa\u00f1\u00eda de investigaci\u00f3n m\u00e9dica creada con el objetivo de generar evidencia cient\u00edfica, desarrollar tecnolog\u00edas innovadoras basadas en la enzima DAO y contribuir al establecimiento de un marco regulatorio en un campo que, en aquel momento, a\u00fan se encontraba en fase emergente.<\/p><p>Bajo su liderazgo, la compa\u00f1\u00eda desarroll\u00f3 una s\u00f3lida cartera de propiedad intelectual y contribuy\u00f3 a la definici\u00f3n de est\u00e1ndares internacionales para productos relacionados con la enzima DAO. Juanjo Duelo es inventor de diversas patentes fundamentales que abarcan nuevas aplicaciones terap\u00e9uticas y funcionales de la DAO, reflejando un nivel de innovaci\u00f3n sin precedentes en este \u00e1mbito. <\/p><p>Tras m\u00e1s de una d\u00e9cada de desarrollo cient\u00edfico y tecnol\u00f3gico, DR Healthcare fue adquirida en 2021 por el grupo brit\u00e1nico <strong>Associated British Foods<\/strong>.<\/p><div>Las invenciones patentadas de Juanjo Duelo, que se detallan a continuaci\u00f3n, reflejan la amplitud y originalidad de sus contribuciones a la investigaci\u00f3n de la enzima DAO, su d\u00e9ficit y sus aplicaciones traslacionales:<\/div><div> <\/div><ul><li><strong>Alimentos funcionales<\/strong> que incorporan Diamino Oxidasa y su uso en el tratamiento de la <strong>migra\u00f1a<\/strong>.(US 12,194,077 B2). <\/li><li>Uso de la <strong>Diamino Oxidasa<\/strong> en el tratamiento o prevenci\u00f3n del trastorno por d\u00e9ficit de atenci\u00f3n e hiperactividad (<strong>TDAH<\/strong>) (US 9,795,654).<\/li><li>Composici\u00f3n con <strong>Diamino Oxidasa<\/strong> para el tratamiento o prevenci\u00f3n de la <strong>fibromialgia<\/strong> o el s\u00edndrome de fatiga cr\u00f3nica (US 20170020993).<\/li><li><strong>Alimentos funcionales<\/strong> que incorporan Diamino Oxidasa y sus aplicaciones (US 20170224784).<\/li><li><strong>Composiciones t\u00f3picas<\/strong> con <strong>Diamino Oxidasa<\/strong> para el tratamiento o prevenci\u00f3n de <strong>enfermedades asociadas a niveles elevados de histamina<\/strong> que cursan con aumento del dolor (US 20160024481).<\/li><li>Composici\u00f3n con <strong>Diamino Oxidasa<\/strong> para la prevenci\u00f3n de los s\u00edntomas de la <strong>resaca<\/strong> (US 20130344136)<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e49980f elementor-align-left elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"e49980f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.daodeficiencyinstitute.com\/es\/equipo-central\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">M\u00e1s informaci\u00f3n<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c692bb4 e-flex e-con-boxed e-con e-parent\" data-id=\"c692bb4\" data-element_type=\"container\" data-e-type=\"container\" id=\"ongoing\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b4a3255 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"b4a3255\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Proyectos en curso<\/h3>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3805537 e-con-full e-flex e-con e-child\" data-id=\"3805537\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-314854b elementor-widget elementor-widget-text-editor\" data-id=\"314854b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Nuestros proyectos en curso incluyen estudios cl\u00ednicos, investigaciones de laboratorio y desarrollos tecnol\u00f3gicos orientados a mejorar la detecci\u00f3n, caracterizaci\u00f3n y manejo del D\u00e9ficit de DAO.<\/strong><br>Las l\u00edneas de trabajo actuales incluyen:<\/p><ul><li>Evaluaci\u00f3n de los resultados cl\u00ednicos de la suplementaci\u00f3n con DAO en poblaciones espec\u00edficas de pacientes<\/li><li>Desarrollo de biomarcadores diagn\u00f3sticos avanzados y herramientas digitales de evaluaci\u00f3n<\/li><li>Estudio de las correlaciones genotipo-fenotipo<\/li><li>Investigaci\u00f3n de los factores diet\u00e9ticos, del microbioma y metab\u00f3licos implicados en el desequilibrio de la histamina<\/li><li>Desarrollo de redes globales de investigaci\u00f3n para la estandarizaci\u00f3n de protocolos diagn\u00f3sticos y terap\u00e9uticos<\/li><li>An\u00e1lisis de la calidad y de la actividad enzim\u00e1tica de los suplementos basados en DAO<\/li><\/ul><p> <\/p><p>Estos proyectos se desarrollan en colaboraci\u00f3n con expertos internacionales, instituciones sanitarias y socios del \u00e1mbito industrial.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2aed09a e-con-full e-flex e-con e-child\" data-id=\"2aed09a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5a49ccc elementor-widget elementor-widget-image\" data-id=\"5a49ccc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"673\" height=\"488\" src=\"https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/marek-levak-GNVxujZ_CxU-unsplash2-2.jpg\" class=\"attachment-2048x2048 size-2048x2048 wp-image-5916\" alt=\"\" srcset=\"https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/marek-levak-GNVxujZ_CxU-unsplash2-2.jpg 673w, https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/marek-levak-GNVxujZ_CxU-unsplash2-2-300x218.jpg 300w, https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/marek-levak-GNVxujZ_CxU-unsplash2-2-600x435.jpg 600w\" sizes=\"(max-width: 673px) 100vw, 673px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-05ac0f9 e-flex e-con-boxed e-con e-parent\" data-id=\"05ac0f9\" data-element_type=\"container\" data-e-type=\"container\" id=\"future\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-464dedf elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"464dedf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Proyectos futuros<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb2fbb6 elementor-widget elementor-widget-heading\" data-id=\"eb2fbb6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Construyendo el futuro del abordaje cl\u00ednico del d\u00e9ficit de DAO<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d2a38a7 elementor-widget elementor-widget-text-editor\" data-id=\"d2a38a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Las futuras iniciativas de investigaci\u00f3n tienen como objetivo profundizar en la comprensi\u00f3n del D\u00e9ficit de DAO y ampliar los recursos cient\u00edficos y cl\u00ednicos disponibles tanto para profesionales como para pacientes.<br><br>Los pr\u00f3ximos proyectos incluyen: <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c2a2163 e-con-full e-flex e-con e-child\" data-id=\"c2a2163\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cffaa90 elementor-widget elementor-widget-image\" data-id=\"cffaa90\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"673\" height=\"488\" src=\"https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/research-future-projects-dao-institute.png\" class=\"attachment-full size-full wp-image-5918\" alt=\"\" srcset=\"https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/research-future-projects-dao-institute.png 673w, https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/research-future-projects-dao-institute-300x218.png 300w, https:\/\/www.daodeficiencyinstitute.com\/wp-content\/uploads\/research-future-projects-dao-institute-600x435.png 600w\" sizes=\"(max-width: 673px) 100vw, 673px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-526b222 e-con-full e-flex e-con e-child\" data-id=\"526b222\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-88bb493 elementor-widget elementor-widget-text-editor\" data-id=\"88bb493\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul><li>Ensayos cl\u00ednicos multic\u00e9ntricos a gran escala<\/li><li>Estudios longitudinales de cohortes para evaluar resultados a largo plazo<\/li><li>Desarrollo de nuevas formulaciones terap\u00e9uticas e innovaciones en nutrici\u00f3n m\u00e9dica<\/li><li>Implementaci\u00f3n de herramientas diagn\u00f3sticas basadas en inteligencia artificial a trav\u00e9s de nuestra plataforma tecnol\u00f3gica<\/li><li>Creaci\u00f3n de nuevas herramientas educativas dirigidas a pacientes.<\/li><li>Ampliaci\u00f3n de registros globales de datos para apoyar la investigaci\u00f3n epidemiol\u00f3gica y traslacional<\/li><\/ul><p> <br>Estos proyectos, orientados al futuro, reflejan el compromiso del Instituto con el avance de la innovaci\u00f3n cient\u00edfica y la mejora de la atenci\u00f3n al paciente a nivel global.<br> <br>Como ocurre con toda investigaci\u00f3n de vanguardia, su desarrollo requiere recursos espec\u00edficos. Para impulsar esta l\u00ednea de trabajo, el Instituto ha creado un<strong> Programa de Partnershi<\/strong>p, que facilita la colaboraci\u00f3n con empresas del \u00e1mbito farmac\u00e9utico y de la industria alimentaria interesadas en el d\u00e9ficit de DAO y en su creciente relevancia cl\u00ednica y cient\u00edfica.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31ac44f elementor-align-left elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"31ac44f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.daodeficiencyinstitute.com\/es\/programa-de-licencia-de-membresia\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Accede al Programa de Colaboraci\u00f3n aqu\u00ed<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Nuestro trabajo Nuestra investigaci\u00f3n se centra en los fundamentos biol\u00f3gicos, las manifestaciones cl\u00ednicas y las implicaciones terap\u00e9uticas del D\u00e9ficit de DAO. Analizamos los factores enzim\u00e1ticos, gen\u00e9ticos, metab\u00f3licos y nutricionales que contribuyen a una degradaci\u00f3n deficiente de la histamina y evaluamos su impacto en patolog\u00edas como los trastornos gastrointestinales funcionales, la cefalea y la migra\u00f1a, la [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-6661","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigaci\u00f3n - D\u00e9ficit de DAO<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.daodeficiencyinstitute.com\/es\/investigacion\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigaci\u00f3n - D\u00e9ficit de DAO\" \/>\n<meta property=\"og:description\" content=\"Nuestro trabajo Nuestra investigaci\u00f3n se centra en los fundamentos biol\u00f3gicos, las manifestaciones cl\u00ednicas y las implicaciones terap\u00e9uticas del D\u00e9ficit de DAO. 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